Treatment

Vyzulta

Also known as Latanoprostene Bunod, Nitric Oxide Donating Prostaglandin, Glaucoma Eye Drop, Eye Pressure Drop, Prostaglandin Analog Drop

Updated May 18, 2026For educational purposes only. Not a substitute for medical advice. See our terms.

Bottom Line

Vyzulta is a once-nightly prescription drop for open-angle glaucoma or ocular hypertension. It is related to prostaglandin drops and adds a nitric oxide donating step.

Vyzulta is latanoprostene bunod ophthalmic solution 0.024%. The label lists it for lowering eye pressure in open-angle glaucoma or ocular hypertension 1.

The label dosing is one drop in the affected eye once daily in the evening 1.

The label warns about iris and eyelid pigmentation, eyelash changes, inflammation, macular swelling, and bacterial keratitis risk with contaminated bottles 1.

How It Works

Vyzulta is a prostaglandin analog. After it enters the eye, it is metabolized into active parts that help lower eye pressure 1.

It is used once nightly. More frequent dosing may lessen pressure lowering.

Who It Helps

Vyzulta may fit people with open-angle glaucoma or ocular hypertension who need pressure lowering.

  • Your doctor wants a prostaglandin-related option.
  • You can dose once nightly.
  • You understand color and eyelash changes can happen.
  • You can attend pressure checks.

Side Effects and Safety

The label warns about iris and eyelid pigmentation, eyelash changes, inflammation, macular swelling, and bacterial keratitis linked to contaminated bottles 1.

Tell your doctor about eye pain, vision decrease, severe redness, discharge, or a history of uveitis.

Cost and Insurance

Vyzulta is a brand-name glaucoma drop. Coverage varies by pharmacy plan.

  • Plans may require prior authorization.
  • Generic latanoprost often costs less.
  • Coupons may help eligible patients.
  • Ask whether the bottle size matches your refill schedule.

Common Questions About Vyzulta

No. Vyzulta is latanoprostene bunod. It is related to prostaglandin drops but is a different prescription medicine.

Next Steps

  1. 1Ask where Vyzulta fits in your pressure plan.
  2. 2Use it once nightly unless your doctor says otherwise.
  3. 3Separate other eye drops by at least 5 minutes.
  4. 4Watch for iris, eyelid, or eyelash changes.
  5. 5Keep pressure checks to confirm your target is met.

Find specialists for Vyzulta

Board-certified ophthalmologists who treat Vyzulta.

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