Treatment

Upneeq / Oxymetazoline 0.1%

Also known as Oxymetazoline Ophthalmic Solution, Droopy Eyelid Drops, Ptosis Eye Drops, Acquired Blepharoptosis Drops, Lid Lifting Drop

Updated May 16, 2026For educational purposes only. Not a substitute for medical advice. See our terms.

Bottom Line

Upneeq is a prescription drop for acquired droopy upper eyelid. It can lift the lid temporarily, but it does not replace a diagnosis.

Upneeq is oxymetazoline hydrochloride ophthalmic solution 0.1%. The label lists it for acquired blepharoptosis, also called acquired droopy upper eyelid 1.

Oxymetazoline can stimulate a small eyelid muscle and raise the upper lid. Randomized trial data showed visual field improvement in acquired ptosis 2.

The label dosing is one drop in one or both droopy eyes once daily 1.

Who It Fits

Upneeq may fit adults with acquired ptosis when an eye doctor has ruled out urgent causes.

Sudden eyelid droop, double vision, unequal pupils, weakness, or trouble speaking needs urgent medical care. These symptoms can signal a nerve or brain problem.

Side Effects

The label lists eye inflammation, eye redness, dry eye, blurred vision, instillation site pain, and headache among adverse reactions 1.

Tell your doctor about heart disease, blood pressure problems, dizziness, eye pain, or worsening redness.

Cost and Insurance

Upneeq is a brand-name prescription drop. Coverage varies by pharmacy benefit plan.

  • Some plans may not cover cosmetic use.
  • Functional ptosis with blocked vision may need documentation.
  • Ask about savings programs or alternatives if the price is high.
  • Ptosis surgery may have different medical coverage rules.

Common Questions About Upneeq

No. It can lift the lid while the drop is active. It does not tighten eyelid tissue permanently.

Next Steps

  1. 1Get an eye exam before treating new eyelid droop.
  2. 2Seek urgent care for sudden droop with double vision, unequal pupils, weakness, or trouble speaking.
  3. 3Use only the prescribed eye drop, not nasal spray.
  4. 4Track lid lift, redness, dryness, and headache after use.
  5. 5Ask whether surgery is better if droop blocks vision all day.

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