Tyrvaya / Varenicline Nasal Spray
Also known as Tyrvaya, Varenicline Nasal Spray, OC-01 Nasal Spray, Dry Eye Nasal Spray, Prescription Dry Eye Spray
Bottom Line
Tyrvaya is a prescription nasal spray for dry eye disease. It works through a nerve pathway in the nose instead of adding a drop to the eye.
Tyrvaya is varenicline solution nasal spray. The prescribing information lists one spray in each nostril twice daily, about 12 hours apart 1.
Varenicline nasal spray stimulates a nerve pathway in the nose that helps the tear gland make more natural tears. A phase 3 randomized trial studied this treatment for signs and symptoms of dry eye disease 2.
The most common side effect is sneezing. Cough, throat irritation, and nose irritation can also happen 1.
How It Works
Tyrvaya does not go into the eye. It is sprayed into the nose, where it stimulates a nerve pathway linked to tear production.
A review of varenicline solution nasal spray describes this pathway and its use in dry eye disease 3.
Side Effects
The label lists sneezing as the most common side effect. Cough, throat irritation, and nose irritation can also happen 1.
Call your doctor for severe nosebleeds, wheezing, swelling, rash, or symptoms that feel unsafe.
Cost and Insurance
Tyrvaya is a brand-name prescription drug. Coverage varies by insurance plan, deductible, pharmacy, and prior authorization rules.
- Ask the pharmacy for the covered price before pickup.
- Ask your clinic about coupons or a plan exception.
- Ask what alternatives are covered if the price is too high.
Common Questions About Tyrvaya
Next Steps
- 1Ask whether your dry eye pattern fits Tyrvaya.
- 2Review nasal allergies, nosebleeds, and current medicines with your doctor.
- 3Use the spray exactly as prescribed.
- 4Track sneezing, cough, throat irritation, and symptom relief.
- 5Ask the pharmacy about coverage before pickup.
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