Tryptyr
Also known as Acoltremon, Acoltremon Ophthalmic Solution, Tryptyr Eye Drops, Dry Eye Prescription Drops, TRPM8 Dry Eye Drop
Bottom Line
Tryptyr is a prescription acoltremon eye drop for dry eye disease. It is used twice daily and is designed to increase natural tear production.
Tryptyr is acoltremon ophthalmic solution 0.003%. The prescribing information lists it for the signs and symptoms of dry eye disease 1.
The label dosing is one drop in each eye twice daily, about 12 hours apart. Each vial is single-use and does not contain preservatives 1.
Acoltremon ophthalmic solution 0.003% was studied for signs and symptoms of dry eye disease in phase 3 studies. The studies measured tear production and symptoms 2.
How It Works
Acoltremon is a TRPM8 thermoreceptor agonist. This means it activates cold-sensing nerve pathways linked to tear production.
The phase 3 acoltremon ophthalmic solution studies evaluated signs and symptoms of dry eye disease 2.
Side Effects
The prescribing information lists instillation-site pain as the most common adverse reaction. This means pain, burning, or stinging after the drop goes in 1.
Call your doctor for severe pain, allergy symptoms, discharge, eye injury, eye infection, or a vision drop.
Cost and Insurance
Tryptyr is a brand-name prescription drug. Coverage depends on your insurance plan, deductible, pharmacy, and prior authorization rules.
Ask your clinic what dry eye testing or past treatment history your plan requires. Ask the pharmacy about coupons or patient support if the copay is high.
Common Questions About Tryptyr
Next Steps
- 1Ask your eye doctor to confirm the type and severity of dry eye.
- 2Use one single-use vial for each scheduled dose unless your doctor says otherwise.
- 3Remove contact lenses before dosing and wait before reinserting them.
- 4Wait at least 5 minutes between Tryptyr and other eye medicines.
- 5Call your doctor for severe pain, allergy symptoms, discharge, or vision change.
Find specialists for Tryptyr
Board-certified ophthalmologists who treat Tryptyr.
Also relevant