How often is Syfovre given?

The label describes one injection every 25 to 60 days [1] .

Is Syfovre the same as Izervay?

No. Syfovre blocks C3. Izervay blocks C5. Both are complement inhibitors.

Can Syfovre cause wet macular degeneration?

Some treated eyes develop wet age-related macular degeneration, so regular scans and symptom checks matter.

When should I call after an injection?

Call right away for severe pain, worsening redness, many new floaters, or a major vision drop.

Treatment

Syfovre / Pegcetacoplan

Also known as Pegcetacoplan, Complement C3 Inhibitor, Geographic Atrophy Injection, Dry AMD Injection, Intravitreal Pegcetacoplan

Updated May 16, 2026·For educational purposes only. Not a substitute for medical advice. See our terms.

Bottom Line

Syfovre is an eye injection for geographic atrophy from age-related macular degeneration. It can slow atrophy growth, but it cannot restore lost retina cells.

Syfovre (pegcetacoplan) is injected into the vitreous gel inside the eye. The current label lists it for geographic atrophy secondary to age-related macular degeneration ¹.

Pegcetacoplan blocks complement protein C3. In two phase 3 trials, pegcetacoplan slowed geographic atrophy growth compared with sham treatment ².

It is a long-term treatment decision. Benefits are measured by slower atrophy growth, not by quick vision improvement.

How Syfovre Works

Syfovre blocks complement protein C3. Complement is part of immune defense. In geographic atrophy, complement activity is linked with retina cell loss ³.

The treatment goal is slower atrophy growth. It is not a vision-restoring medicine.

Risks and Side Effects

Syfovre can cause injection-related side effects. It can also raise the chance of wet age-related macular degeneration in some eyes.

Eye discomfort or scratchy feeling.
Floaters.
Red spot on the white of the eye.
Infection or retinal detachment.
New wet macular degeneration.

Same-day warning: Call the retina office for severe pain, worsening redness, new floaters, or a major vision drop.

Cost and Insurance

Syfovre is usually billed to medical insurance because it is given in a retina office. Costs can include the drug, imaging, office visit, and injection procedure.

Prior authorization is common.
Coverage often requires confirmed geographic atrophy on imaging.
Out-of-pocket cost depends on deductible, copay, coinsurance, and assistance programs.
Some plans compare Syfovre with Izervay before approval.

Ask the retina office for a benefits check before treatment starts.

Common Questions About Syfovre

It is designed to slow atrophy growth. It usually does not make vision better quickly.

Next Steps

1Bring prior macula scans to your Syfovre consultation.
2Ask whether atrophy location and vision goals make treatment worthwhile.
3Confirm insurance authorization and expected out-of-pocket cost.
4Plan repeat visits every 25 to 60 days if treatment starts.
5Call the retina office right away for severe pain, new floaters, or major vision drop after injection.

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